Diagnostic test of Immature Granulocyte Ratio (IG Ratio) to detect Early-Onset Neonatal Sepsis (EONS)

Background: Based on the onset of events, most common neonatal sepsis is early-onset (EONS), which occurs within first 72 hours life. Blood culture gold standard for EONS, but this examination takes a long time to provide results. However, latest method obtained determine shift left granulocytic image by counting Immature Granulocyte (IG). This study aims evaluate accuracy IG Ratio diagnosing EONS in neonates suspected having sepsis. Methods: A cross-sectional observational was conducted among 60 patients consecutively, who met inclusion criteria from January June 2022 at Prof. dr. I.G.N.G Ngoerah Hospital, Bali. Variables assessed included age, gender, delivery methods, birth status, birthweight, blood culture, complete count (CBC), I/T ratio, and ratio. Data were analyzed using SPSS version 23 Windows. Results: The cut-off point 2.21 (AUC=0.670 (0,490-0,851); p=0.041; OR: 8.021 (2.283-28.185); p=0.001), had sensitivity 64.7% specificity 81.4% results also Negative Predictive Value (NPV) 85.35 Positive (PPV) 57.89. Conclusion: has risk factor times higher with